RHEO™ is a connective tissue allograft flowable matrix. It’s derived from chorion-free human placental tissue and amniotic fluid, cryopreserved to maintain the viability of the intercellular messengers. RHEO™ retains the biologic functionality that ensures symmetrical structure development, growth, and repair of the soft tissue by acting as a biologic matrix for use in filling defects, or for points of localized inflammation.

The placental Extracellular Matrix (ECM) modulates correct cellular reconstruction rather than scar tissue formation. This ECM includes growth factors, fibronectin, laminin, hyaluronic acid, proteoglycans, and other proteins. Anti-inflammatory and anti-fibrotic proteins in placental ECMs reduce inflammation, fibrous tissue growth, and potential scar tissue formation as they downregulate TGF-Beta1, suppress proinflammatory cytokines, and inhibit MMPs and fibroblast formation.

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